The main objective of this work was to evaluate the potential antidiabetic effect of Citrus grandis peel in alloxan induced diabetic rats. Diabetes was induced by injecting single dose administration of alloxan (150 mg/kg, i.p). The induction of diabetes was confirmed after 3 days of alloxan injection and the rats with fasting blood glucose levels were greater than 200 mg/dl were considered to be diabetic and used further for study. In the present study 30 rats were divided into 6 groups, each group containing 5 animals; non diabetic group, diabetic group, glibenclamide (10 mg/kg, p.o) treated group, Citrus grandis peel extract treated groups (100 mg/kg, 200 mg/kg, 400 mg/kg, p.o). Each extract was administrated orally daily for 14 days. On the last day, the blood was collected from all the groups of rats which have fasted overnight by puncturing the retro-orbital of the eye under mild ether anesthetic condition. The statistical data indicated that the different dose of Citrus grandis peel significantly decreases the level of fasting blood glucose level in alloxan induced in rats. Histopathological examination of heart indicated that the administration of Citrus grandis peel was showed significant decrease in necrotic lesions, perivascular oedema and infiltrations of cells as compared to diabetic rats. Our investigation has clearly indicated that ethanolic extract of Citrus grandis peel showed antihyperglycemic activity.
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